Renin-angiotensin-aldosterone system and G-protein beta-3 subunit gene polymorphisms in salt-sensitive essential hypertension

• Published in: Journal of human hypertension Vol. 17; no. 3; pp. 187 - 191
• Main Authors: Pamies-Andreu, E, Ramirez-Lorca, R, Stiefel García-Junco, P, Muñiz-Grijalbo, O, Vallejo-Maroto, I, Garcia Morillo, S, Miranda-Guisado, M L, Ortíz, J V, Carneado de la Fuente, J
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2003; Nature Publishing Group
• Subjects: Adult; Aldosterone; Aldosterone - blood; Aldosterone synthase; Alleles; Angiotensin; Angiotensin II; Blood pressure; Blood Volume - physiology; Epidemiology; Female; G proteins; Gene polymorphism; Genetic aspects; Genotype; Health Administration; Heterotrimeric GTP-Binding Proteins - genetics; Heterotrimeric GTP-Binding Proteins - physiology; Humans; Hypertension; Hypertension - chemically induced; Hypertension - genetics; Hypertension - physiopathology; Insertion; Male; Medicine; Medicine & Public Health; original-article; Peptidyl-dipeptidase A; Physiological aspects; Polymerase chain reaction; Polymorphism; Polymorphism, Genetic - physiology; Protein G; Proteins; Public Health; Renin; Renin - blood; Renin-angiotensin system; Renin-Angiotensin System - genetics; Renin-Angiotensin System - physiology; Salt; Sodium Chloride, Dietary - adverse effects; Sodium Chloride, Dietary - metabolism; Spain; aldosterone synthase; genetic polymorphisms; renin–angiotensin system; salt sensitivity; protein G

Approximately 50% of hypertensive patients are salt sensitive (they increase their Blood Pressure in response to sodium intake or volume expansion). Mechanisms underlying salt sensitivity are not completely elucidated although there is evidence that they may be genetically determined. The aim of thi...