Multiple-dose tolerability, pharmacokinetics, and pharmacodynamics of ponesimod, an S1P1 receptor modulator: favorable impact of dose up-titration - Brossard, P; Scherz, M; Halabi, A; Maatouk, H; Krause, A; Dingemanse, J (Journal of clinical pharmacology, 2014)
Keywords: Adolescent; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Lymphocyte Count; Male; Middle Aged; Models, Biological; Receptors, Lysosphingolipid - antagonists & inhibitors; Thiazoles - administration & dosage; Thiazoles - adverse effects; Thiazoles - pharmacokinetics; Thiazoles - pharmacology; Young Adult; S1P1 receptor modulator; pharmacokinetics; ponesimod; healthy subjects; pharmacodynamics