Comparative study of procalcitonin and C-reactive protein in patients with sepsis

Background: The early diagnosis and appropriate therapy of sepsis is a challenge in intensive care units in spite of the advances in critical care medicine. Aim of the study: The aim is to study and compare procalcitonin (PCT) and C-reactive protein (CRP) levels in patients admitted with the diagnos...

Full description

Saved in:
Bibliographic Details
Published inJournal of natural science, biology and medicine Vol. 11; no. 2; pp. 93 - 99
Main Authors Patil, Harsha, Patil, Virendra
Format Journal Article
LanguageEnglish
Published Mumbai Wolters Kluwer India Pvt. Ltd 01.07.2020
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Background: The early diagnosis and appropriate therapy of sepsis is a challenge in intensive care units in spite of the advances in critical care medicine. Aim of the study: The aim is to study and compare procalcitonin (PCT) and C-reactive protein (CRP) levels in patients admitted with the diagnosis of sepsis to the critical care unit. Materials and Methods: This was a prospective observational study conducted at the teaching hospital over a period of 1 year. All patients with evidence of sepsis were enrolled for this study and were underwent relevant history, laboratory biochemical and imaging investigations including PCT and CRP levels. Results: A total of 64 patients with the diagnosis of sepsis were enrolled in this study. A total of 43 (67.19%) were male and 21 (32.81%) were female. The mean and standard deviation for the Acute Physiology and Chronic Health Evaluation II (APACHE-II) score was 18 (±7), Sepsis-Related Organ Failure Assessment (SOFA) score was 9 (±5), papillary thyroid cancer as 19.07 (±7.02 ng/ml), and CRP was 33.5 (±15.7 mg/l). About 56.25% of patients had PCT in the range of 2-10 ng/ml, 28.13% had >10 ng/ml, and 14.06% had between 0.5 and 1.9 ng/ml. A total of 43 (67.19%) patients had a positive culture for organisms and 21 (32.81%) had sterile with no growth on culture with P < 0.001. The mean (20.74 ± 7.13). PCT levels were significantly high in Gram-negative organisms compared to (9.71 ± 0.96). Gram-positive organisms with P < 0.02. APACHE-II score, SOFA score, and CRP had a positive correlation with serum PCT levels and negative correlation with creatinine, pH, Glasgow Coma Scale and PaO2level. Multivariate analysis revealed that the serum PCT level was better correlated with the variable of sepsis than to CRP (P < 0.01). Conclusion: The present study concludes that the PCT was statistically significantly correlated with the severity of sepsis, APACHE-II, and SOFA score than CRP. The higher level of PCT was associated with Gram-negative sepsis and mortality.
AbstractList Background: The early diagnosis and appropriate therapy of sepsis is a challenge in intensive care units in spite of the advances in critical care medicine. Aim of the study: The aim is to study and compare procalcitonin (PCT) and C-reactive protein (CRP) levels in patients admitted with the diagnosis of sepsis to the critical care unit. Materials and Methods: This was a prospective observational study conducted at the teaching hospital over a period of 1 year. All patients with evidence of sepsis were enrolled for this study and were underwent relevant history, laboratory biochemical and imaging investigations including PCT and CRP levels. Results: A total of 64 patients with the diagnosis of sepsis were enrolled in this study. A total of 43 (67.19%) were male and 21 (32.81%) were female. The mean and standard deviation for the Acute Physiology and Chronic Health Evaluation II (APACHE-II) score was 18 (±7), Sepsis-Related Organ Failure Assessment (SOFA) score was 9 (±5), papillary thyroid cancer as 19.07 (±7.02 ng/ml), and CRP was 33.5 (±15.7 mg/l). About 56.25% of patients had PCT in the range of 2–10 ng/ml, 28.13% had >10 ng/ml, and 14.06% had between 0.5 and 1.9 ng/ml. A total of 43 (67.19%) patients had a positive culture for organisms and 21 (32.81%) had sterile with no growth on culture with P < 0.001. The mean (20.74 ± 7.13). PCT levels were significantly high in Gram-negative organisms compared to (9.71 ± 0.96). Gram-positive organisms with P < 0.02. APACHE-II score, SOFA score, and CRP had a positive correlation with serum PCT levels and negative correlation with creatinine, pH, Glasgow Coma Scale and PaO2level. Multivariate analysis revealed that the serum PCT level was better correlated with the variable of sepsis than to CRP (P < 0.01). Conclusion: The present study concludes that the PCT was statistically significantly correlated with the severity of sepsis, APACHE-II, and SOFA score than CRP. The higher level of PCT was associated with Gram-negative sepsis and mortality.
Audience Academic
Author Patil, Harsha
Patil, Virendra
Author_xml – sequence: 1
  givenname: Harsha
  surname: Patil
  fullname: Patil, Harsha
  organization: Department of Microbiology, Krishna Institute of Medical Sciences, Deemed to be University, Karad, Maharashtra
– sequence: 2
  givenname: Virendra
  surname: Patil
  fullname: Patil, Virendra
  organization: Department of Medicine, Krishna Institute of Medical Sciences, Deemed to be University, Karad, Maharashtra
BookMark eNqNkcFv2yAUxtGUSUuz3ne0tFMPTgFjMMc06tJWWast7RlhwBmpDZnBS_vflzWrokg7FN4T0uP3wdP7TsDIeWcA-ILglCBYnG9cqLvpze3q4rtAAsMPYIwx5jljkI3AGHJGc05p9QmchrCBaZUpcDEGP-a-28peRvvHZCEO-jnzTbbtvZKtstE76zLpdDbPeyPVK5Uuo0nlFNukMy6GbGfjryyYbbDhM_jYyDaY03_nBDx8u7yfX-XLu8X1fLbM15ijmFeEM9lISWpJCNeqkriqK0l1yUtU8qKmuIGwIaTRnGmqjUKUIoY5LGWtYFVMwNf9u6mf34MJUWz80Lv0pcBlgRkirCIHai1bI6xrfOyl6mxQYkYLBCFNmajpf6i0temsSrNubKofCc6OBImJ5imu5RCCuF79fDdbLZbH7GzP7nwbTR8e22FnetEZ_ej8TiAo_votXv0WB78FL8SbkcUL9CijUQ
ContentType Journal Article
Copyright COPYRIGHT 2020 Medknow Publications and Media Pvt. Ltd.
2020. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: COPYRIGHT 2020 Medknow Publications and Media Pvt. Ltd.
– notice: 2020. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID 8GL
ISR
3V.
7X7
7XB
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M7P
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
DOI 10.4103/jnsbm.JNSBM_1_20
DatabaseName Gale In Context: High School
Gale In Context: Science
ProQuest Central (Corporate)
ProQuest_Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
AUTh Library subscriptions: ProQuest Central
ProQuest Natural Science Collection
ProQuest One Community College
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection (Proquest) (PQ_SDU_P3)
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Health & Medical Collection (Alumni Edition)
Biological Science Database
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
DatabaseTitle Publicly Available Content Database
ProQuest Central Student
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Central
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest Central (Alumni)
DatabaseTitleList Publicly Available Content Database

Database_xml – sequence: 1
  dbid: BENPR
  name: AUTh Library subscriptions: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 2229-7707
EndPage 99
ExternalDocumentID A631006100
10.4103/jnsbm.JNSBM_1_20_93_Comparat
GeographicLocations India
GeographicLocations_xml – name: India
GroupedDBID 8FE
8FH
8GL
AAKDD
ABDBF
ABPTK
ACGFS
ACPRK
ADACO
ADBBV
AFKRA
ALMA_UNASSIGNED_HOLDINGS
BBNVY
BENPR
BHPHI
EAD
EAP
EAS
EPL
EST
ESX
GICCO
GX1
HCIFZ
IAO
IHR
IHW
ISR
ITC
KQ8
LK8
M7P
M~E
OBODZ
OK1
P2P
PIMPY
PROAC
RMW
RPM
W3E
7X7
8FI
8FJ
ABUWG
ALIPV
AOIJS
CCPQU
EOJEC
FYUFA
HMCUK
UKHRP
3V.
7XB
8FK
AZQEC
DWQXO
GNUQQ
K9.
PQEST
PQQKQ
PQUKI
PRINS
ID FETCH-LOGICAL-g291t-8497afaa4ba449dc8a28b8a6d5951593b62f00f44fd97d6dec166172905abc083
IEDL.DBID BENPR
ISSN 0976-9668
IngestDate Thu Oct 10 20:27:52 EDT 2024
Fri Feb 23 00:15:48 EST 2024
Fri Feb 02 04:19:52 EST 2024
Thu Aug 01 19:35:48 EDT 2024
Thu Aug 01 20:30:24 EDT 2024
Tue Jan 05 18:26:10 EST 2021
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Keywords procalcitonin
Gram-negative organism
C-reactive protein
Sepsis-Related Organ Failure Assessment score
Acute Physiology and Chronic Health Evaluation-II score
sepsis
Language English
License http://creativecommons.org/licenses/by-nc-sa/4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-g291t-8497afaa4ba449dc8a28b8a6d5951593b62f00f44fd97d6dec166172905abc083
OpenAccessLink https://www.proquest.com/docview/2532714784?pq-origsite=%requestingapplication%
PQID 2532714784
PQPubID 2035653
PageCount 7
ParticipantIDs proquest_journals_2532714784
gale_infotracmisc_A631006100
gale_infotracacademiconefile_A631006100
gale_incontextgauss_ISR_A631006100
gale_incontextgauss_8GL_A631006100
wolterskluwer_medknow_10_4103_jnsbm_JNSBM_1_20_93_Comparat
ProviderPackageCode W3E
RMW
PublicationCentury 2000
PublicationDate 20200701
PublicationDateYYYYMMDD 2020-07-01
PublicationDate_xml – month: 7
  year: 2020
  text: 20200701
  day: 01
PublicationDecade 2020
PublicationPlace Mumbai
PublicationPlace_xml – name: Mumbai
PublicationTitle Journal of natural science, biology and medicine
PublicationYear 2020
Publisher Wolters Kluwer India Pvt. Ltd
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Publisher_xml – name: Wolters Kluwer India Pvt. Ltd
– name: Medknow Publications and Media Pvt. Ltd
– name: Medknow Publications & Media Pvt. Ltd
SSID ssj0000500523
Score 2.2083259
Snippet Background: The early diagnosis and appropriate therapy of sepsis is a challenge in intensive care units in spite of the advances in critical care medicine....
SourceID proquest
gale
wolterskluwer
SourceType Aggregation Database
Publisher
StartPage 93
SubjectTerms C-reactive protein
Care and treatment
Comparative analysis
Creatinine
Critical care
Diagnosis
Infection
Intensive care units
Multivariate analysis
Papillary thyroid cancer
Procalcitonin
Sepsis
Title Comparative study of procalcitonin and C-reactive protein in patients with sepsis
URI http://www.jnsbm.org/article.asp?issn=0976-9668;year=2020;volume=11;issue=2;spage=93;epage=99;aulast=Patil;type=0
https://www.proquest.com/docview/2532714784
Volume 11
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3da9UwFA_uDsQh4tdwOkcQwae6NkmT1hfZLptzeC-6ObhvIWmaMefaudzhv-85ubleCyr0qT2U0vOR3_nIL4S8tt7xwkN2Im1ZQYJSeYiDtcokN5ZxL7j12NGdTOXRmTielbNUcAtprHIZE2Ogdn2DNfJdVnKmCqEq8f76R4anRmF3NR2hsUbWGTI3jcj6_sH088nvKktexrpnJNxTEqkoq0WvUhQ53_3WBXv19nh6uj_RhWZ_Ccsb5P7PHtvW4TJOrf-x9hw-JA8SaKR7Cy0_Infa7jG5O0lt8Sfky3jF4U0jYSztPcW1yXxvwGW7i46aztFxBhAxBjga-RngNlyJWjVQrMnS0F6Hi_CUnB0efB0fZemshOyc1cU8q0StjDdGWCNE7ZrKsMpWRrqyRsTCrWQ-z70Q3tXKSdc2hUTwUuelsQ3gsE0y6vqufUaoyyHogGZt4VrwaGMlb30LeQpkftYrtUVe4V_SyB7R4XjKubkNQVcfPuk9if0CQGT5P4Q-np4MhN4kId_Pb0xj0pYA-A5kpRpIbg8kwQea4eOlxnTywaBXFrNF3g20qK8WWw01ZEBoCDoagl4Zgq65Xmru-f_f_YLcY5iCxwnebTKa39y2LwGnzO0OWVMztZNM8heD0ukb
link.rule.ids 315,786,790,12077,21409,27946,27947,31743,33768,43334,43829
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3ta9QwGA86wRdEfMXp1CCCn-raJk1Sv8g8nLd5d6Db4L6FpGnG3NbO5Yb_vs-Ty3kWVOin9qGUPi_5PS_5hZA31jtWeMhOhK0UJCjKQxysZSaYsSXznFmPHd3pTIyP-P68mqeCW0hjlauYGAO16xuskW-XFStlwaXiHy5-ZHhqFHZX0xEa18kNzhhD7nw5l79rLHkVq56Rbk8KJKJUy04lL3K2_b0L9vzd_uzg41QXuvxLUL5D7v7ssWkdTuPM-h8rz-59ci9BRrqz1PEDcq3tHpKb09QUf0S-jtYM3jTSxdLeU1yZzFkDDtuddNR0jo4yAIgxvNHIzgC34UrEqoFiRZaG9iKchMfkaPfT4WicpZMSsuOyLhaZ4rU03hhuDee1a5QplVVGuKpGvMKsKH2ee869q6UTrm0KgdClzitjG0BhT8hG13ftU0JdDiEH9GoL14I_GytY61vIUiDvs17KTfIa_5JG7ogOh1OOzVUIWn2e6B2B3QLAY_k_hPYOvg2E3iYh3y8uTWPShgD4DuSkGkhuDSTBA5rh45XGdPLAoNf2skneD7Soz5cbDTXkP2gIOhqCXhuCrpleae7Z_9_9itwaH04nerI3-_Kc3C4xGY-zvFtkY3F51b4AxLKwL6NZ_gInWum5
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Comparative+study+of+procalcitonin+and+C-reactive+protein+in+patients+with+sepsis&rft.jtitle=Journal+of+natural+science%2C+biology+and+medicine&rft.au=Patil%2C+Harsha&rft.au=Patil%2C+Virendra&rft.date=2020-07-01&rft.pub=Medknow+Publications+and+Media+Pvt.+Ltd&rft.issn=0976-9668&rft.eissn=2229-7707&rft.volume=11&rft.issue=2&rft.spage=93&rft_id=info:doi/10.4103%2Fjnsbm.JNSBM_1_20&rft.externalDBID=ISR&rft.externalDocID=A631006100
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0976-9668&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0976-9668&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0976-9668&client=summon