HLA-DR expression, cytokines and bioactive lipids in sepsis

• Published in: Archives of medical science Vol. 10; no. 2; pp. 325 - 335
• Main Author: Das, Undurti
• Format: Journal Article
• Language: English
• Published: Poland Termedia Publishing House 12.05.2014
• Subjects: State of the Art Papers; ghrelin; lipoxins; cold-inducible RNA binding protein; nociceptin; maresins; resolvins; nitrolipids; protectins; bioactive lipids; sepsis

Sepsis accounts for more than 200,000 deaths annually in the USA alone. Both inflammatory and anti-inflammatory responses occur simultaneously in sepsis, the early phase dominated by the hyperinflammatory response and the late phase by immunosuppression. This late immunosuppression phase leads to lo...