Uncarialins J—M from Uncaria rhynchophylla and Their Anti‐depression Mechanism in Unpredictable Chronic Mild Stress‐Induced Mice via Activating 5‐HT1A Receptor - Yu, Zhen‐Long; Bai, Rong; Zhou, Jun‐Jun; Huang, Hui‐Lian; Zhao, Wen‐Yu; Huo, Xiao‐Kui; Yang, Ya‐Hui; Luan, Zhi‐Lin; Zhang, Bao‐Jing; Sun, Cheng‐Peng; Ma, Xiao‐Chi (Chinese journal of chemistry, 2021)
Keywords: 5‐HT1A receptor; Amino acids; Antidepressants; Binding sites; Central nervous system; Central nervous system diseases; Chemical compounds; Chemistry; Chemistry, Multidisciplinary; Circular dichroism; Depression; Dichroism; Hirsuteine; Indoles; Mental depression; Molecular docking; Monoterpene indole alkaloids; Mutation; NMR; Nuclear magnetic resonance; Physical Sciences; Quantum chemistry; Receptors; Science & Technology; Signal transduction; Site‐directed amino acid mutation; Structural analysis; Uncaria rhynchophylla; ANTIDEPRESSANT; DOWN-REGULATION; INCREASES; Depression; HT1A receptor; ISORHYNCHOPHYLLINE; MESSENGER-RNA; SEROTONIN 1A; Site‐ DISORDER; DOPAMINE; Hirsuteine; directed amino acid mutation; INDOLE ALKALOIDS; 5‐ EXPRESSION; Monoterpene indole alkaloids