Altered cytokine export and apoptosis in mice deficient in interleukin-1Beta converting enzyme

The interleukin-1beta (IL-1beta) converting enzyme (ICE) processes the inactive IL-1beta precursor to the proinflammatory cytokine. Adherent monocytes from mice harboring a disrupted ICE gene did not export IL-1beta or interleukin-1alpha after stimulation with lipopolysaccharide.

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 267; no. 5206; p. 2000
Main Authors Kuida, Keisuke, Lippke, Judith A, Ku, George, Harding, Matthew W, Livingston, David J, Su, Michael S.-S, Flacell, Richard A
Format Journal Article
LanguageEnglish
Published Washington American Association for the Advancement of Science 31.03.1995
The American Association for the Advancement of Science
Subjects
Biology
Body Weight
Cell death
Cell regulation
Cellular control mechanisms
Enzymes
Immunocytochemistry
Stimuli
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Summary:The interleukin-1beta (IL-1beta) converting enzyme (ICE) processes the inactive IL-1beta precursor to the proinflammatory cytokine. Adherent monocytes from mice harboring a disrupted ICE gene did not export IL-1beta or interleukin-1alpha after stimulation with lipopolysaccharide.
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ISSN:0036-8075
1095-9203