Bucindolol: a beta-blocker for the treatment of heart failure

• Published in: Formulary (Cleveland, Ohio) Vol. 44; no. 6; p. 166
• Main Authors: Reinhart, Kurt M, White, C. Michael
• Format: Journal Article
• Language: English
• Published: North Olmsted Intellisphere, LLC 01.06.2009; MultiMedia Healthcare Inc
• Subjects: ACE inhibitors; Adrenergic receptors; Beta blockers; Clinical trials; Disease; Diuretics; Drug dosages; Drug therapy; FDA approval; Heart attacks; Heart failure; Hospitalization; Mortality; Patient outcomes; Patients; Pharmacokinetics; Studies; United States

Two beta-blockers are approved for the treatment of heart failure (HF): carvedilol and metoprolol XL. Bucindolol, an investigational agent under FDA review for the treatment of HF, is a nonspecific beta-blocker with weak alpha-blocking properties that may or may not possess intrinsic sympathomimetic...