Transcriptional profiling reveals progeroid Ercc1(-/Δ) mice as a model system for glomerular aging

• Published in: BMC genomics Vol. 14; p. 559
• Main Authors: Schermer, Bernhard, Bartels, Valerie, Frommolt, Peter, Habermann, Bianca, Braun, Fabian, Schultze, Joachim L, Roodbergen, Marianne, Hoeijmakers, Jan Hj, Schumacher, Björn, Nürnberg, Peter, Dollé, Martijn Et, Benzing, Thomas, Müller, Roman-Ulrich, Kurschat, Christine E
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.08.2013; BioMed Central
• Subjects: Age; Age Factors; Aging; Aging - genetics; Animals; Biology; Cell death; Cluster Analysis; Colleges & universities; Comparative analysis; Disease Models, Animal; DNA damage; DNA microarrays; DNA-Binding Proteins - genetics; Endonucleases - genetics; Female; Gene expression; Gene Expression Profiling; Gene Expression Regulation; Genetic aspects; Genetic transcription; Genomes; Genomics; Genotype & phenotype; Insulin; Kidney diseases; Kidney Diseases - etiology; Kidney failure; Kidney Glomerulus - metabolism; Kidneys; Male; Medical research; Medicine, Experimental; Mice; Mice, Knockout; Molecular Sequence Annotation; Mortality; Older people; Principal Component Analysis; Principal components analysis; Progeria - genetics; Progeria - metabolism; Public health; Rodents; Signal Transduction; Germany

Aging-related kidney diseases are a major health concern. Currently, models to study renal aging are lacking. Due to a reduced life-span progeroid models hold the promise to facilitate aging studies and allow examination of tissue-specific changes. Defects in genome maintenance in the Ercc1(-/Δ) pro...