Assessment of bioequivalence of ciprofloxacin in healthy male subjects using HPLC

• Published in: Pakistan journal of pharmaceutical sciences Vol. 21; no. 3; p. 299
• Main Authors: Khan, Muhammad Khalid, Khan, Muhammad Farid
• Format: Journal Article
• Language: English
• Published: Pakistan Pakistan Journal of Pharmaceutical Sciences 01.07.2008
• Subjects: Administration, Oral; Adult; Anti-Infective Agents - administration & dosage; Anti-Infective Agents - blood; Anti-Infective Agents - pharmacology; Antibacterial agents; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Ciprofloxacin; Ciprofloxacin - administration & dosage; Ciprofloxacin - blood; Ciprofloxacin - pharmacokinetics; Cross-Over Studies; Humans; Male; Tablets; Therapeutic Equivalency

Pharmacokinetics and bioequivalence studies of two brands of ciprofloxacin 500 mg (Ciprofloxacin & Ciproxin) were evaluated in 14 healthy male volunteers after oral administration. The drug was analyzed in plasma samples by using HPLC. The peak plasma concentrations of (2.28+/-0.04 mg/L) and (1....