Assessment of bioequivalence of ciprofloxacin in healthy male subjects using HPLC

Pharmacokinetics and bioequivalence studies of two brands of ciprofloxacin 500 mg (Ciprofloxacin & Ciproxin) were evaluated in 14 healthy male volunteers after oral administration. The drug was analyzed in plasma samples by using HPLC. The peak plasma concentrations of (2.28+/-0.04 mg/L) and (1....

Full description

Saved in:
Bibliographic Details
Published inPakistan journal of pharmaceutical sciences Vol. 21; no. 3; p. 299
Main Authors Khan, Muhammad Khalid, Khan, Muhammad Farid
Format Journal Article
LanguageEnglish
Published Pakistan Pakistan Journal of Pharmaceutical Sciences 01.07.2008
Subjects
Administration, Oral
Adult
Anti-Infective Agents - administration & dosage
Anti-Infective Agents - blood
Anti-Infective Agents - pharmacology
Antibacterial agents
Chemistry, Pharmaceutical
Chromatography, High Pressure Liquid
Ciprofloxacin
Ciprofloxacin - administration & dosage
Ciprofloxacin - blood
Ciprofloxacin - pharmacokinetics
Cross-Over Studies
Humans
Male
Tablets
Therapeutic Equivalency
Online AccessGet full text

Cover

More Information
Summary:Pharmacokinetics and bioequivalence studies of two brands of ciprofloxacin 500 mg (Ciprofloxacin & Ciproxin) were evaluated in 14 healthy male volunteers after oral administration. The drug was analyzed in plasma samples by using HPLC. The peak plasma concentrations of (2.28+/-0.04 mg/L) and (1.9+/-0.02 mg/L) was attained in about 1.71 hours and 2.00 hours for both Test and Reference ciprofloxacin, respectively. The mean +/- SE values for total area under the curve (AUC) were 11.91+/-0.26 and 13.11+/-0.27 h.mg/L for both test and reference tablets respectively. This study indicated that all the differences in bioequivalence parameters for both ciprofloxacin formulations are statistically non-significant, hence both formulations are bioequivalent.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Undefined-3
ISSN:1011-601X