Hyperosmotic perfusion of the beating rat heart and the role of the Na+/K+/2Cl- co-transporter and the Na+/H+ exchanger

• Published in: Basic research in cardiology Vol. 95; no. 1; pp. 19 - 27
• Main Authors: Falck, G, Schjøtt, J, Bruvold, M, Krane, J, Skarra, S, Jynge, P
• Format: Journal Article
• Language: English
• Published: Germany 01.02.2000
• Subjects: Animals; Chloride Channels - physiology; Heart - physiology; Hydrogen-Ion Concentration; Male; Myocardial Contraction; Osmosis; Perfusion; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers - physiology; Sodium-Potassium-Exchanging ATPase - physiology; Water-Electrolyte Balance

The aim of the present study was to investigate the role of the Na+/K+/2Cl- co-transporter and the Na+/H+ exchanger on contractile function and electrolyte regulation during hyperosmotic perfusion of the heart. Langendorff perfused rat hearts were subjected to hyperosmolal perfusion in 10-min interv...