Xenical in the prevention of diabetes in obese subjects (XENDOS) study: A randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients

• Published in: Diabetes care Vol. 27; no. 1; pp. 155 - 161
• Main Authors: TORGERSON, Jarl S, HAUPTMAN, Jonathan, BOLDRIN, Mark N, SJÖSTRÖM, Lars
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 2004
• Subjects: Adult; Biological and medical sciences; Body Mass Index; Care and treatment; Diabetes Mellitus - prevention & control; Diabetes. Impaired glucose tolerance; Double-Blind Method; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Energy Intake; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Evaluation; Female; Glucose Tolerance Test; Humans; Lactones - therapeutic use; Life Style; Lipase - antagonists & inhibitors; Male; Medical sciences; Metabolic diseases; Middle Aged; Obesity; Obesity - blood; Obesity - drug therapy; Orlistat; Placebos; Prevention; Prospective Studies; Type 2 diabetes; Sweden; Endocrinopathy; Type 2 diabetes; Human; Obesity; Enzyme; Nutrition disorder; Enzyme inhibitor; Triacylglycerol lipase; Esterases; Carboxylic ester hydrolases; Prevention; Randomization; Orlistat; Hydrolases; Nutritional status; Life style

It is well established that the risk of developing type 2 diabetes is closely linked to the presence and duration of overweight and obesity. A reduction in the incidence of type 2 diabetes with lifestyle changes has previously been demonstrated. We hypothesized that adding a weight-reducing agent to...