A Glycosylated Covalent Organic Framework Equipped with BODIPY and CaCO3 for Synergistic Tumor Therapy

• Published in: Angewandte Chemie International Edition Vol. 59; no. 41; pp. 18042 - 18047
• Main Authors: Guan, Qun, Zhou, Le‐Le, Lv, Fan‐Hong, Li, Wen‐Yan, Li, Yan‐An, Dong, Yu‐Bin
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 05.10.2020
• Edition: International ed. in English
• Subjects: Calcium (intracellular); Calcium (mitochondrial); Calcium buffering; Calcium carbonate; Calcium ions; calcium overload; cancer; Cancer therapies; CD44 antigen; Cell death; covalent organic frameworks; Gastrointestinal tract; Glycosaminoglycans; Intracellular; Mitochondria; Nanoparticles; Overloading; Photodynamic therapy; reticular chemistry; Synergism; Tumor cells

Ca2+, a ubiquitous but nuanced modulator of cellular physiology, is meticulously controlled intracellularly. However, intracellular Ca2+ regulation, such as mitochondrial Ca2+ buffering capacity, can be disrupted by 1O2. Thus, the intracellular Ca2+ overload, which is recognized as one of the import...