Catalytic sp3–sp3 Functionalisation of Sulfonamides: Late‐Stage Modification of Drug‐Like Molecules

• Published in: Chemistry : a European journal Vol. 23; no. 7; pp. 1494 - 1497
• Main Authors: Abdulla, Othman, Clayton, Adam D., Faulkner, Robert A., Gill, Duncan M., Rice, Craig R., Walton, Scarlett M., Sweeney, Joseph B.
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 31.01.2017
• Subjects: Binders; catalysis; Chemistry; late-stage functionalisation; palladium; sigma receptor; sulfonamides

A new application of Pd‐catalysed allylation is reported that enables the synthesis of a range of branched sp3‐functionalised sulfonamides, a compound class for which few reported methods exist. By reacting benzyl sulfonamides with allylic acetates in the presence of Pd0 catalysts and base at room t...