Brain and whole-body imaging of nociceptin/orphanin FQ peptide receptor in humans using the PET ligand 11C-NOP-1A - Lohith, Talakad G; Zoghbi, Sami S; Morse, Cheryl L; Araneta, Maria F; Barth, Vanessa N; Goebl, Nancy A; Tauscher, Johannes T; Pike, Victor W; Innis, Robert B; Fujita, Masahiro (The Journal of nuclear medicine (1978), 2012)
Keywords: Adult; Biotransformation; Brain - diagnostic imaging; Bridged Bicyclo Compounds, Heterocyclic - adverse effects; Bridged Bicyclo Compounds, Heterocyclic - pharmacokinetics; Female; Humans; Image Processing, Computer-Assisted; Isotope Labeling; Linear Models; Magnetic Resonance Imaging; Male; Models, Statistical; Nociceptin; Opioid Peptides - metabolism; Positron-Emission Tomography - methods; Radiometry; Radiopharmaceuticals - administration & dosage; Radiopharmaceuticals - pharmacokinetics; Spiro Compounds - adverse effects; Spiro Compounds - pharmacokinetics; Tissue Distribution; Whole Body Imaging - methods