Patient-Derived Xenograft Models of Colorectal Cancer: Procedures for Engraftment and Propagation

• Published in: Methods in molecular biology (Clifton, N.J.) Vol. 1765; p. 307
• Main Authors: Burgenske, Danielle M, Monsma, David J, MacKeigan, Jeffrey P
• Format: Journal Article
• Language: English
• Published: United States 2018
• Subjects: Animals; Colon - pathology; Colorectal Neoplasms - pathology; Humans; Mice; Mice, Nude; Mice, SCID; Primary Cell Culture - instrumentation; Primary Cell Culture - methods; Rectum - pathology; Tumor Cells, Cultured; Xenograft Model Antitumor Assays - instrumentation; Xenograft Model Antitumor Assays - methods; Tumor heterogeneity; Tumorgraft; Drug screening; Colorectal cancer; Patient-derived xenograft; Preclinical in vivo efficacy

Preclinical compounds tested in animal models often demonstrate limited efficacy when transitioned into patients. As a result, individuals are assigned to treatment regimens that may be ineffective at treating their disease. The development of more clinically relevant models, such as patient-derived...