Brown adipose TRX2 deficiency activates mtDNA-NLRPB to impair thermogenesis and protect against diet-induced insulin resistance

• Published in: The Journal of clinical investigation Vol. 132; no. 9
• Main Authors: Huang, Yanrui, Zhou, Jenny H, Zhang, Haifeng, Canfran-Duque, Alberto, Singh, Abhishek K, Perry, Rachel J, Shulman, Gerald I, Fernandez-Hernando, Carlos, Min, Wang
• Format: Journal Article
• Language: English
• Published: American Society for Clinical Investigation 01.05.2022
• Subjects: Brown adipose tissue; Development and progression; Health aspects; Inflammation; Insulin resistance; Medical research; Medicine, Experimental; Mitochondrial DNA; Obesity; Physiological aspects; Thermogenesis; Thioredoxin; United States

Brown adipose tissue (BAT), a crucial heat-generating organ, regulates whole-body energy metabolism by mediating thermogenesis. BAT inflammation is implicated in the pathogenesis of mitochondrial dysfunction and impaired thermogenesis. However, the link between BAT inflammation and systematic metabo...