IL-1[beta]-dependent extravasation of preexisting lung-restricted autoantibodies during lung transplantation activates complement and mediates primary graft dysfunction

• Published in: The Journal of clinical investigation Vol. 132; no. 20
• Main Authors: Yang, Wenbin, Cerier, Emily Jeong, Nunez-Santana, Felix L, Wu, Qiang, Yan, Yuanqing, Kurihara, Chitaru, Liu, Xianpeng, Yeldandi, Anjana, Khurram, Nigar, Avella-Patino, Diego, Sun, Haiying, Budinger, G.R. Scott, Kreisel, Daniel, Mohanakumar, Thalachallour, Lecuona, Emilia, Bharat, Ankit
• Format: Journal Article
• Language: English
• Published: American Society for Clinical Investigation 15.10.2022
• Subjects: Autoantibodies; Graft rejection; Health aspects; Interleukin-1; Lungs; Physiological aspects; Risk factors; Transplantation; United States

Preexisting lung-restricted autoantibodies (LRAs) are associated with a higher incidence of primary graft dysfunction (PGD), although it remains unclear whether LRAs can drive its pathogenesis. In syngeneic murine left lung transplant recipients, preexisting LRAs worsened graft dysfunction, which wa...