Nonhematopoietic antigen blocks memory programming of alloreactive [CD8.sup.+] T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation

• Published in: The Journal of clinical investigation Vol. 120; no. 11; pp. 3855 - 3868
• Main Authors: Flutter, Barry, Edwards, Noha, Fallah-Arani, Farnaz, Henderson, Stephen, Chai, Jian-Guo, Sivakumaran, Shivajanani, Ghorashian, Sara, Bennett, Clare L, Freeman, Gordon J, Sykes, Megan, Chakraverty, Ronjon
• Format: Journal Article
• Language: English
• Published: American Society for Clinical Investigation 01.11.2010
• Subjects: Bone marrow; CD8 lymphocytes; Genetic aspects; Graft versus host reaction; Physiological aspects; Risk factors; Transplantation; United Kingdom

Allogeneic blood or BM transplantation (BMT) is the most commonly applied form of adoptive cellular therapy for cancer. In this context, the ability of donor T cells to respond to recipient antigens is coopted to generate graft-versus-tumor (GVT) responses. The major reason for treatment failure is...