Scale up of a granulation phenomenon : During the drying of an active pharmaceutical ingredient

• Published in: Pharmaceutical Technology Vol. 29; no. 10; pp. 80 - 86
• Main Authors: KUKURA, Joseph, IZZO, Bill, ORELLA, Charles
• Format: Magazine Article Trade Publication Article
• Language: English
• Published: Duluth, MN Advanstar Communications 01.10.2005; Intellisphere, LLC; MultiMedia Healthcare Inc
• Subjects: Biological and medical sciences; Crystallization; Electron microscopes; General pharmacology; Laboratories; Manufacturers; Manufacturing; Medical sciences; Moisture content; Pharmaceutical industry; Pharmaceutical technology. Pharmaceutical industry; Pharmaceuticals; Pharmacology. Drug treatments; Physical properties; Product development; R&D; Research & development; Washers & dryers; United States; United States > US; Active ingredient; Pharmaceutical technology; Granulation; Drying

A drug product's formulation processes and dissolution rates can be sensitive to changes in the physical nature of the active pharmaceutical ingredient (API). Consequently, manufacturers must ensure that the development and scale-up of the final manufacturing step of an API maintain consistency...