GSK-3[beta] at the Intersection of Neuronal Plasticity and Neurodegeneration

• Published in: Journal of neural transplantation & plasticity Vol. 2019
• Main Authors: Jaworski, Tomasz, Banach-Kasper, Ewa, Gralec, Katarzyna
• Format: Journal Article
• Language: English
• Published: John Wiley & Sons, Inc 31.05.2019
• Subjects: Glycogen; Health aspects; Nervous system diseases; Neurons; Neurophysiology; Physiological aspects; Protein kinases; Synthesis

In neurons, Glycogen Synthase Kinase-3[beta] (GSK-3j3) has been shown to regulate various critical processes underlying structural and functional synaptic plasticity. Mouse models with neuron-selective expression or deletion of GSK-3[beta] present behavioral and cognitive abnormalities, positioning...