Metabolic network as a progression biomarker of premanifest Huntington's disease

• Published in: The Journal of clinical investigation Vol. 123; no. 9; pp. 4076 - 4096
• Main Authors: Tang, Chris C, Feigin, Andrew, Ma, Yilong, Habeck, Christian, Paulsen, Jane S, Leenders, Klaus L, Teune, Laura K, Oostrom, Joost C.H. van, Guttman, Mark, Dhawan, Vijay, Eidelberg, David
• Format: Journal Article
• Language: English
• Published: American Society for Clinical Investigation 01.09.2013
• Subjects: Biological markers; Cell metabolism; Development and progression; Huntington's chorea

Background. The evaluation of effective disease-modifying therapies for neurodegenerative disorders relies on objective and accurate measures of progression in at-risk individuals. Here we used a computational approach to identify a functional brain network associated with the progression of preclin...