Protein kinase A negatively regulates Ca.sup.2+ signalling in Toxoplasma gondii

• Published in: PLoS biology Vol. 16; no. 9
• Main Authors: Uboldi, Alessandro D, Wilde, Mary-Louise, McRae, Emi A, Stewart, Rebecca J, Dagley, Laura F, Yang, Luning, Katris, Nicholas J, Hapuarachchi, Sanduni V, Coffey, Michael J, Lehane, Adele M, Botte, Cyrille Y, Waller, Ross F, Webb, Andrew I, McConville, Malcolm J, Tonkin, Christopher J
• Format: Journal Article
• Language: English
• Published: Public Library of Science 12.09.2018
• Subjects: Calcium ions; Cellular signal transduction; Microbiological research; Physiological aspects; Protein kinases; Toxoplasma

The phylum Apicomplexa comprises a group of obligate intracellular parasites that alternate between intracellular replicating stages and actively motile extracellular forms that move through tissue. Parasite cytosolic Ca.sup.2+ signalling activates motility, but how this is switched off after invasi...