Multicentric reticulohistiocytosis associated arthritis responding to anti-TNF and methotrexate

• Published in: Acta clinica belgica (English ed. Online) Vol. 66; no. 1; p. 66
• Main Authors: De Knop, K.J, Aerts, N.E, Ebo, D.G, Van Offel, J.F, Stevens, W.J, De Clerck, L.S
• Format: Journal Article
• Language: English
• Published: Acta Clinica Belgica 01.01.2011
• Subjects: Arthritis; Care and treatment; Health aspects; Methotrexate; Skin; Tumor necrosis factor

We present a patient with therapy resistant multicentric reticulohistiocytosis (MRH). MRH is a rare granulomatous, multisystem disease characterised most frequently by disfiguring papulonodular skin lesions and sometimes a destructive polyarthritis, though any organ can be involved. Abnormal histioc...