Increased lipid availability for three days reduces whole body glucose uptake, impairs muscle mitochondrial function and initiates opposing effects on PGC-1[alpha] promoter methylation in healthy subjects

• Published in: PloS one Vol. 12; no. 12; p. e0188208
• Main Authors: Eldor, Roy, Norton, Luke, Fourcaudot, Marcel, Galindo, Cynthia, DeFronzo, Ralph A, Abdul-Ghani, Muhammad
• Format: Journal Article
• Language: English
• Published: Public Library of Science 20.12.2017
• Subjects: Analysis; Health aspects; High fat diet; Mitochondrial myopathies; Physiological aspects; Risk factors; Transcriptional coactivators; Israel

FFA and FFA metabolites cause insulin resistance and impair beta cell function. The goal of our research was to examine whether elevation of plasma FFA impairs mitochondrial function and alters PGC-1[alpha] promoter methylation. In this uncontrolled, change from baseline study design, insulin sensit...