Gene-Trap Mutagenesis Identifies Mammalian Genes Contributing to Intoxication by Clostridium perfringens [epsilon]-Toxin

• Published in: PloS one Vol. 6; no. 3; p. e17787
• Main Authors: Ivie, Susan E, Fennessey, Christine M, Sheng, Jinsong, Rubin, Donald H, McClain, Mark S
• Format: Journal Article
• Language: English
• Published: Public Library of Science 11.03.2011
• Subjects: Amino acids; Analysis; Cell death; Cells (Biology); DNA microarrays; Gene expression; Gene mutation; Genetic research; Health aspects; Hepatitis A; RNA

The Clostridium perfringens [epsilon]-toxin is an extremely potent toxin associated with lethal toxemias in domesticated ruminants and may be toxic to humans. Intoxication results in fluid accumulation in various tissues, most notably in the brain and kidneys. Previous studies suggest that the toxin...