Potentiation of [DELTA]F508- and G551D-CFTR-Mediated Cl.sup.- Current by Novel Hydroxypyrazolines

• Published in: PloS one Vol. 11; no. 2
• Main Authors: Park, Jinhong, Khloya, Poonam, Seo, Yohan, Kumar, Satish, Lee, Ho K, Jeon, Dong-Kyu, Jo, Sungwoo, Sharma, Pawan K, Namkung, Wan
• Format: Journal Article
• Language: English
• Published: Public Library of Science 10.02.2016
• Subjects: Care and treatment; Cystic fibrosis; Diagnosis; Health aspects; Isoflavones

The most common mutation of CFTR, affecting approximately 90% of CF patients, is a deletion of phenylalanine at position 508 (F508del, [DELTA]F508). Misfolding of [DELTA]F508-CFTR impairs both its trafficking to the plasma membrane and its chloride channel activity. To identify small molecules that...