Knockdown of Long Non-Coding RNA UCA1 Increases the Tamoxifen Sensitivity of Breast Cancer Cells through Inhibition of Wnt/[beta]-Catenin Pathway

• Published in: PloS one Vol. 11; no. 12; p. e0168406
• Main Authors: Liu, Hongying, Wang, Gang, Yang, Lili, Qu, Jianjun, Yang, Zhihui, Zhou, Xiangyu
• Format: Journal Article
• Language: English
• Published: Public Library of Science 15.12.2016
• Subjects: Breast cancer; Dosage and administration; Drug resistance; Drug therapy; Genetic aspects; RNA; Tamoxifen; China

Acquired resistance to tamoxifen remains a major obstacle in breast cancer (BC) treatment, since the underlying mechanism has not been fully elucidated. The long non-coding RNA (lncRNA) urothelial carcinoma-associated 1 (UCA1) has been recently shown to be dysregulated and plays important roles in p...