Reversible Disruption of Pre-Pulse Inhibition in Hypomorphic-Inducible and Reversible CB1.sup.-/- Mice

• Published in: PloS one Vol. 7; no. 4; p. e35013
• Main Authors: Marongiu, Maria Franca, Poddie, Daniela, Porcu, Susanna, Manchinu, Maria Francesca, Castelli, Maria Paola, Sogos, Valeria, Bini, Valentina, Frau, Roberto, Caredda, Elisabetta, Collu, Maria, Ristaldi, Maria Serafina
• Format: Journal Article
• Language: English
• Published: Public Library of Science 27.04.2012
• Subjects: Genes; Genetically modified organisms; House mouse; Physiological aspects; Schizophrenia

Although several genes are implicated in the pathogenesis of schizophrenia, in animal models for such a severe mental illness only some aspects of the pathology can be represented (endophenotypes). Genetically modified mice are currently being used to obtain or characterize such endophenotypes. Sinc...