5Z-7-Oxozeanol Inhibits the Effects of TGF[beta]1 on Human Gingival Fibroblasts

• Published in: PloS one Vol. 10; no. 4
• Main Authors: Kuk, Hanna, Hutchenreuther, James, Murphy-Marshman, Hannah, Carter, David, Leask, Andrew
• Format: Journal Article
• Language: English
• Published: Public Library of Science 30.04.2015
• Subjects: Analysis; Collagen; DNA microarrays; RNA; Transforming growth factors

Transforming growth factor (TGF)[beta] acts on fibroblasts to promote the production and remodeling of extracellular matrix (ECM). In adult humans, excessive action of TGF[beta] is associated with fibrotic disease and fibroproliferative conditions, including gingival hyperplasia. Understanding how t...