Human Ovarian Tumor Cells Escape [gamma][delta] T Cell Recognition Partly by Down Regulating Surface Expression of MICA and Limiting Cell Cycle Related Molecules

• Published in: PloS one Vol. 6; no. 9; p. e23348
• Main Authors: Lu, Jingwei, Aggarwal, Reeva, Kanji, Suman, Das, Manjusri, Joseph, Matthew, Pompili, Vincent, Das, Hiranmoy
• Format: Journal Article
• Language: English
• Published: Public Library of Science 14.09.2011
• Subjects: Apoptosis; Cell cycle; Ovarian cancer; T cells

Mechanisms of human V[gamma]2V[delta]2 T cell-mediated tumor immunity have yet to be fully elucidated. At least some tumor cell recognition is mediated by NKG2D-MICA interactions. Herein, by using MTT assay and PI-BrdU co-staining and Western-blot, we show that these V[gamma]2V[delta]2 T cells can l...