Monoclonal Antibodies to the V2 Domain of MN-rgp120: Fine Mapping of Epitopes and Inhibition of [alpha]4[beta]7 Binding

• Published in: PloS one Vol. 7; no. 6; p. e39045
• Main Authors: Nakamura, Gerald R, Fonseca, Dora P. A. J, O'Rourke, Sara M, Vollrath, Aaron L, Berman, Phillip W
• Format: Journal Article
• Language: English
• Published: Public Library of Science 13.06.2012
• Subjects: Amino acids; Analysis; Antigenic determinants; Health aspects; HIV; HIV infections; Infection; Integrins; Medical research; Monoclonal antibodies; T cells; Vaccination; Vaccines

Recombinant gp120 (MN-rgp120) was a major component of the AIDSVAX B/E vaccine used in the RV144 trial. This was the first clinical trial to show that vaccination could prevent HIV infection in humans. A recent RV144 correlates of protection study found that protection correlated with the presence o...