Hippocampal expression of murine TNF[alpha] results in attenuation of amyloid deposition in vivo

• Published in: Molecular neurodegeneration Vol. 6; p. 16
• Main Authors: Chakrabarty, Paramita, Herring, Amanda, Ceballos-Diaz, Carolina, Das, Pritam, Golde, Todd E
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 16.02.2011; BioMed Central
• Subjects: Amyloid beta-protein; Hippocampus (Brain); Immune system; Pathology; Physiological aspects; Proteins; Rodents; Studies; Tumor necrosis factor; United States

Fibrillar amyloid [beta] (fA[beta]) peptide is the major component of A[beta] plaques in the brains of Alzheimer's disease (AD) patients. Inflammatory mediators have previously been proposed to be drivers of A[beta] pathology in AD patients by increasing amyloidogenic processing of APP and prom...