Evidence of intraneuronal A[beta] accumulation preceding tau pathology in the entorhinal cortex

• Published in: Acta neuropathologica Vol. 136; no. 6; p. 901
• Main Authors: Welikovitch, Lindsay A, Do Carmo, Sonia, Maglóczky, Zsófia, Szocsics, Péter, Loke, János, Freund, Tamás, Cuello, A. Claudio
• Format: Journal Article
• Language: English
• Published: Springer 01.12.2018
• ISSN: 0001-6322
• DOI: 10.1007/s00401-018-1922-z

Growing evidence gathered from transgenic animal models of Alzheimer's disease (AD) indicates that the intraneuronal accumulation of amyloid-[beta] (A[beta]) peptides is an early event in the AD pathogenesis, producing cognitive deficits before the deposition of insoluble plaques. Levels of sol...