Estimating the contribution of surfactant replacement therapy to the alveolar pool: An in vivo study based on 13C natural abundance in rabbits

• Published in: Journal of mass spectrometry. Vol. 53; no. 7; pp. 560 - 564
• Main Authors: Giambelluca, Sonia, Ricci, Francesca, Simonato, Manuela, Correani, Alessio, Casiraghi, Costanza, Storti, Matteo, Cogo, Paola, Salomone, Fabrizio, Carnielli, Virgilio Paolo
• Format: Journal Article
• Language: English
• Published: Bognor Regis Wiley Subscription Services, Inc 01.07.2018
• Subjects: 13C natural abundance; Abundance; Alveoli; animal models; Bronchus; carbon; Carbon 13; Feasibility studies; GC‐C‐IRMS; humans; In vivo methods and tests; in vivo studies; Infants; Isotopes; Isotopic enrichment; Kinetics; Lecithin; Lungs; Mass spectrometry; Mass spectroscopy; Mineral nutrients; Molecular chains; Nutrients; Organic chemistry; palmitates; Palmitic acid; Pharmacology; Phosphatidylcholine; Phospholipids; premature birth; Rabbits; RDS; stable isotope; stable isotopes; surfactant; Surfactants; therapeutics; Therapy; tracer techniques; Tracers

Variation of the isotopic abundance of selected nutrients and molecules has been used for pharmacological and kinetics studies under the premise that the administered molecule has a different isotopic enrichment from the isotopic background of the recipient subject. The aim of this study is to test...