Heterosexual transmission of subtype C HIV-1 selects consensus-like variants without increased replicative capacity or interferona resistance

• Published in: PLoS pathogens Vol. 11; no. 9
• Main Authors: Deymier, Martin J, Ende, Zachary, Fenton-May, Angharad E, Dilernia, Dario A, Kilembe, William, Allen, Susan A, Borrow, Persephone, Hunter, Eric
• Format: Journal Article
• Language: English
• Published: Public Library of Science 01.09.2015
• Subjects: Disease transmission; Genetic aspects; HIV infection; Host-virus relationships

Heterosexual transmission of HIV-1 is characterized by a genetic bottleneck that selects a single viral variant, the transmitted/founder (TF), during most transmission events. To assess viral characteristics influencing HIV-1 transmission, we sequenced 167 near full-length viral genomes and generate...