Restricted TcR [beta] chain CDR3 clonotype is associated with resolved acute hepatitis B subjects

• Published in: BMC infectious diseases Vol. 21; no. 1
• Main Authors: Xiao, Dangsheng, Wang, Ju, Chen, Zhitao, Jin, Xiuyuan, Xie, Yirui, Yan, Dong, Yang, Jiezuan
• Format: Journal Article
• Language: English
• Published: BioMed Central Ltd 23.01.2021
• Subjects: Antigen receptors, T cell; Clonal selection theory; Comparative analysis; Complementarity-determining regions; Development and progression; Health aspects; Hepatitis B; Prognosis; Receptors; T cells; Viral antigens; China

T cells play an important role in the prognosis of hepatitis B virus (HBV) infection, and are involved in the seroconversion of a patient from HBsAb negative to positive. To compare the T-cell receptor [beta]-chain variable region (TcRBV) complementarity-determining region 3 (CDR3) in subjects with...