Cathelicidin LL37 Promotes Epithelial and Smooth-Muscle-Like Differentiation of Adipose-Derived Stem Cells through the Wnt/[beta]-Catenin and NF-[kappa]B Pathways

• Published in: Biochemistry (Moscow) Vol. 82; no. 11; p. 1336
• Main Authors: Li, Yongwei, Shan, Zhengfei, Yang, Bin, Yang, Diandong, Men, Changping, Cui, Yuanshan, Wu, Jitao
• Format: Journal Article
• Language: English
• Published: Springer 01.11.2017
• Subjects: Antimicrobial peptides; Cathelicidins; Cell differentiation; Epithelial cells; Health aspects; Physiological aspects; Stem cells; Transcription factors; Wnt proteins

Ureter reconstruction is a difficult procedure in urology. Adipose-derived stem cells (ADSCs), along with multipotency and self-renewal capacity, are a preferred choice for tissue engineering-based ureteral reconstruction. We explored the synergic role of cathelicidin LL37 (LL37) in epithelial and s...