The Salmonella typhimurium/mammalian microsomal assay. A report of the U.S. Environmental Protection Agency Gene-Tox Program

The Salmonella assay has been in use for almost 15 years and can be defined as a routine test for mutagenicity and for predicting potential carcinogenicity. It detects the majority of animal carcinogens and consequently plays an important role in safety assessment. The test is also routinely used as...

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Bibliographic Details
Published inMutation research Vol. 168; no. 2; p. 69
Main Authors Kier, L D, Brusick, D J, Auletta, A E, Von Halle, E S, Brown, M M, Simmon, V F, Dunkel, V, McCann, J, Mortelmans, K, Kier, L E
Format Journal Article
LanguageEnglish
Published Netherlands 01.09.1986
Subjects
Animals
Biotransformation
Carcinogens
Microsomes, Liver - metabolism
Mutagenicity Tests - standards
Mutagens
Research Design
Salmonella typhimurium - drug effects
Structure-Activity Relationship
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Summary:The Salmonella assay has been in use for almost 15 years and can be defined as a routine test for mutagenicity and for predicting potential carcinogenicity. It detects the majority of animal carcinogens and consequently plays an important role in safety assessment. The test is also routinely used as the frontline screen for environmental samples (complex mixtures) isolated from air, water and food. This role will continue to remain an area of growth as or because sample volumes associated with these testing areas are generally very limited and more extensive testing is generally impossible. While this test, like all others, has some limitations, it is recommended that it be regularly included in all genetic testing batteries.
ISSN:0027-5107