A perturbed gene network containing PI3K-AKT, RAS-ERK and WNT-[beta]-catenin pathways in leukocytes is linked to ASD genetics and symptom severity

• Published in: Nature neuroscience Vol. 22; no. 10; pp. 1624 - 1634
• Main Authors: Gazestani, Vahid H, Pramparo, Tiziano, Nalabolu, Srinivasa, Kellman, Benjamin P, Murray, Sarah, Lopez, Linda, Pierce, Karen
• Format: Journal Article
• Language: English
• Published: Nature Publishing Group 01.10.2019
• Subjects: Development and progression; Genetic aspects; Genetic markers; Health aspects; Leukocytes; Pervasive developmental disorders; United States

Hundreds of genes are implicated in autism spectrum disorder (ASD), but the mechanisms through which they contribute to ASD pathophysiology remain elusive. Here we analyzed leukocyte transcriptomics from 1- to 4-year-old male toddlers with ASD or typical development from the general population. We d...