IMycobacterium avium/I subsp. Iparatuberculosis/I Antigens Elicit a Strong IgG4 Response in Patients with Multiple Sclerosis and Exacerbate Experimental Autoimmune Encephalomyelitis

• Published in: Life (Basel, Switzerland) Vol. 13; no. 7
• Main Authors: Cossu, Davide, Tomizawa, Yuji, Yokoyama, Kazumasa, Sakanishi, Tamami, Momotani, Eiichi, Sechi, Leonardo A, Hattori, Nobutaka
• Format: Journal Article
• Language: English
• Published: MDPI AG 01.06.2023
• Subjects: Antigens; Complications and side effects; Development and progression; Health aspects; Immune response; Immunoglobulin G; Immunological research; Johne's disease; Multiple sclerosis; Physiological aspects; Italy; Japan
• ISSN: 2075-1729; 2075-1729
• DOI: 10.3390/life13071437

Neuroinflammation can be triggered by microbial products disrupting immune regulation. In this study, we investigated the levels of IgG1, IgG2, IgG3, and IgG4 subclasses against the heat shock protein (HSP)70[sub.533–545] peptide and lipopentapeptide (MAP_Lp5) derived from Mycobacterium avium subsp....