Perturbation and resilience of the gut microbiome up to 3 months after [beta]-lactams exposure in healthy volunteers suggest an important role of microbial [beta]-lactamases

• Published in: Microbiome Vol. 12; no. 1
• Main Authors: d'Humières, Camille, Delavy, Margot, Alla, Laurie, Ichou, Farid, Gauliard, Emilie, Ghozlane, Amine, Levenez, Florence, Galleron, Nathalie, Quinquis, Benoit, Pons, Nicolas, Mullaert, Jimmy, Bridier-Nahmias, Antoine, Condamine, Bénédicte, Touchon, Marie, Rainteau, Dominique, Lamazière, Antonin, Lesnik, Philippe, Ponnaiah, Maharajah, Lhomme, Marie, Sertour, Natacha, Devente, Savannah, Docquier, Jean-Denis, Bougnoux, Marie-Elisabeth, Tenaillon, Olivier, Magnan, Mélanie, Ruppé, Etienne, Grall, Nathalie, Duval, Xavier, Ehrlich, Dusko, Mentré, France, Denamur, Erick, Rocha, Eduardo P. C, Le Chatelier, Emmanuelle, Burdet, Charles
• Format: Journal Article
• Language: English
• Published: BioMed Central Ltd 12.03.2024
• Subjects: Analysis; Antibiotics; Beta lactamases; Drug resistance in microorganisms; Metabolites; Microbiota (Symbiotic organisms); France; Massachusetts; California

Antibiotics notoriously perturb the gut microbiota. We treated healthy volunteers either with cefotaxime or ceftriaxone for 3 days, and collected in each subject 12 faecal samples up to day 90. Using untargeted and targeted phenotypic and genotypic approaches, we studied the changes in the bacterial...