Mesenchymal stem cells desensitize castration-resistant prostate cancer to docetaxel chemotherapy via inducing TGF-[beta]1-mediated cell autophagy

• Published in: Cell & bioscience Vol. 11; no. 1
• Main Authors: Yu, Yang, Yang, Fu-han, Zhang, Wen-tao, Guo, Ya-dong, Ye, Lin, Yao, Xu-dong
• Format: Journal Article
• Language: English
• Published: BioMed Central Ltd 07.01.2021
• Subjects: Antimitotic agents; Antineoplastic agents; Apoptosis; Bone morphogenetic proteins; Cancer; Chemotherapy; Cholecystokinin; Enzyme-linked immunosorbent assay; Enzymes; Prostate cancer; RNA; Stem cells; Transforming growth factors

Mesenchymal stem cells (MSCs) have been proved to drive castration resistant prostate cancer (CRPC). In this study, we aim to investigate the contribution of MSCs to the development of docetaxel resistance in CRPC cells and its potential mechanisms. The effect of MSCs on CRPC cells resistance to doc...