Secreted Frizzled Related Protein 4: A Novel Marker of Pancreatic Beta Cell Dysfunction In Prediabetic Obese Subjects

• Published in: Indian journal of clinical biochemistry Vol. 32; no. S1; p. S143
• Main Authors: Mukesh, Kumar, Neelima, Singh, Kumar, Sharma Ashish
• Format: Journal Article
• Language: English
• Published: Springer 24.05.2022
• Subjects: Apoptosis; Dextrose; Glucose; Pancreatic beta cells; Prediabetic state

INTRODUCTION: Secreted frizzled-related protein 4 (SFRP4) is a proinflammatory cytokine and a potent regulator of Wnt/[beta] catenin signaling pathway. It causes apoptosis of [beta] cells and decreases expression of [Ca2.sup.+] channels thereby its concentration is increased in the obesity and impai...