Epigallocathechin-3 Gallate Attenuates Volume Overload-Induced Cardiac Hypertrophy in Rats

Cardiac hypertrophy, or an increase in heart size, is an important risk factor for cardiac morbidity and mortality. Epigallocathechin-3 gallate (EGCG) is one of major bioactive polyphenols present in green tea and believed to ameliorate cardiovascular disease. Therefore, we investigated whether EGCG...

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Bibliographic Details
Published inLaboratory animal research Vol. 22; no. 4
Main Authors Hao, J. (Chungbuk National University, Cheongju, Republic of Korea), Ahn, H.Y. (Chungbuk National University, Cheongju, Republic of Korea), Kim, C.H. (Chungbuk National University, Cheongju, Republic of Korea), E-mail: kch@chungbuk.ac.kr
Format Journal Article
LanguageEnglish
Published 01.12.2006
Subjects
CARDIOPATHIE
EGCG
ENFERMEDADES CARDIACAS
HEART DISEASES
HIPERTROFIA
HYPERTROPHIE
HYPERTROPHY
volume overload
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ISSN1738-6055
2233-7660

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Summary:Cardiac hypertrophy, or an increase in heart size, is an important risk factor for cardiac morbidity and mortality. Epigallocathechin-3 gallate (EGCG) is one of major bioactive polyphenols present in green tea and believed to ameliorate cardiovascular disease. Therefore, we investigated whether EGCG and green tea extract (GTE) supplementation could attenuate the development of cardiac hypertrophy induced by volume overload. Cardiac hypertrophy was induced by aortocaval shunt (ACS) in rats and evaluated by determining the heart to body weight (HW/BW) ratio or cross sectional area.
Bibliography:2007000537
L50
ISSN:1738-6055
2233-7660