Histone H3K4 methylation regulates hyphal growth, secondary metabolism and multiple stress responses in Fusarium graminearum

• Published in: Environmental microbiology Vol. 17; no. 11; pp. 4615 - 4630
• Main Authors: Liu, Ye, Liu, Na, Yin, Yanni, Chen, Yun, Jiang, Jinhua, Ma, Zhonghua
• Format: Journal Article
• Language: English
• Published: England Blackwell Science 01.11.2015; Blackwell Publishing Ltd; Wiley Subscription Services, Inc
• Subjects: Biosynthesis; Cell Wall - metabolism; cell walls; deoxynivalenol; eukaryotic cells; Fungal Proteins - genetics; Fungal Proteins - metabolism; Fusarium - genetics; Fusarium - metabolism; Fusarium - pathogenicity; Fusarium graminearum; genes; Histone-Lysine N-Methyltransferase - genetics; Histone-Lysine N-Methyltransferase - metabolism; histones; Histones - genetics; Histones - metabolism; hyphae; Hyphae - growth & development; lysine; Metabolism; Methylation; microbial growth; mutants; Mycophenolic Acid - pharmacology; Phosphorylation; plant pathogenic fungi; Secondary Metabolism - physiology; stress response; Stress, Physiological - physiology; Trichothecenes - biosynthesis; Two-Hybrid System Techniques; Virulence; Western blotting; Yeasts

Histone H3 lysine 4 methylation (H3K4me) is generally associated with actively transcribed genes in a variety of eukaryotes. The function of H3K4me in phytopathogenic fungi remains unclear. Here, we report that FgSet1 is predominantly responsible for mono‐, di‐ and trimethylation of H3K4 in Fusarium...