Efficacy of Primary Prevention Interventions When Fasting and Postglucose Dysglycemia Coexist: Analysis of the Indian Diabetes Prevention Programmes (IDPP-1 and IDPP-2)

• Published in: Diabetes care Vol. 33; no. 10; pp. 2164 - 2168
• Main Authors: Ramachandran, Ambady, Arun, Nanditha, Shetty, Ananth Samith, Snehalatha, Chamukuttan
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.10.2010
• Subjects: Adult; Analysis; Biological and medical sciences; blood; blood glucose; Blood Glucose - drug effects; Blood Glucose - metabolism; complications; Dextrose; Diabetes; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 2 - etiology; Diabetes Mellitus, Type 2 - prevention & control; Diabetes. Impaired glucose tolerance; drug effects; drug therapy; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; etiology; Etiopathogenesis. Screening. Investigations. Target tissue resistance; fasting; Fasting - blood; Female; Glucose; Glucose Intolerance; Glucose Intolerance - complications; Glucose Intolerance - drug therapy; Glucose Intolerance - therapy; glucose tolerance; Humans; Hypoglycemic Agents; Hypoglycemic Agents - pharmacology; Hypoglycemic Agents - therapeutic use; Insulin resistance; Intervention; Life Style; lifestyle; Male; Medical sciences; Metabolic diseases; metabolism; metformin; Metformin - pharmacology; Metformin - therapeutic use; methods; Middle Aged; Miscellaneous; Original Research; pharmacology; Plasma; Prevention; prevention & control; Primary Prevention; Primary Prevention - methods; Proportional Hazards Models; Public health. Hygiene; Public health. Hygiene-occupational medicine; Regression analysis; Statistical analysis; Studies; Survival analysis; therapeutic use; therapy; Asia; India; Endocrinopathy; Human; Evaluation; Sanitary program; Fasting; Nutrition; Diabetes mellitus; Metabolic diseases; Prevention; Target tissue resistance; Hyperglycemia; Primary; Indian; Insulin resistance; Fast; Endocrinology

OBJECTIVE: Impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) have different pathophysiological abnormalities, and their combination may influence the effectiveness of the primary prevention tools. The hypothesis was tested in this analysis, which was done in a pooled sample of two...