Age‐related changes in mitochondrial antioxidant enzyme Trx2 and TXNIP–Trx2–ASK1 signal pathways in the auditory cortex of a mimetic aging rat model: changes to Trx2 in the auditory cortex

• Published in: The FEBS journal Vol. 282; no. 14; pp. 2758 - 2774
• Main Authors: Sun, Hai‐Ying, Hu, Yu‐Juan, Zhao, Xue‐Yan, Zhong, Yi, Zeng, Ling‐Ling, Chen, Xu‐Bo, Yuan, Jie, Wu, Jing, Sun, Yu, Kong, Wen, Kong, Wei‐Jia
• Format: Journal Article
• Language: English
• Published: England Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies 01.07.2015; Blackwell Publishing Ltd
• Subjects: age‐related hearing loss; Aging; animal models; Animals; Antioxidants; Antioxidants - metabolism; apoptosis; Apoptosis - genetics; auditory cortex; Auditory Cortex - cytology; Auditory Cortex - metabolism; Auditory Cortex - physiology; Auditory Cortex - ultrastructure; Carrier Proteins - genetics; Carrier Proteins - metabolism; chronic exposure; cortex; Enzymes; galactose; Gene Expression Regulation; Hearing loss; homeostasis; Malondialdehyde - metabolism; MAP Kinase Kinase Kinase 5 - genetics; MAP Kinase Kinase Kinase 5 - metabolism; Mitochondria; Mitochondria - metabolism; oxidant stress; Oxidative Stress; pathogenesis; phenotype; rats; Rats, Sprague-Dawley; reactive oxygen species; signal transduction; speech; Superoxide Dismutase - metabolism; Thioredoxins - genetics; Thioredoxins - metabolism; thioredoxin 2; apoptosis; oxidant stress; thioredoxin 2; auditory cortex; age-related hearing loss

Age‐associated degeneration in the central auditory system, which is defined as central presbycusis, can impair sound localization and speech perception. Research has shown that oxidative stress plays a central role in the pathological process of central presbycusis. Thioredoxin 2 (Trx2), one member...