Age‐related changes in mitochondrial antioxidant enzyme Trx2 and TXNIP–Trx2–ASK1 signal pathways in the auditory cortex of a mimetic aging rat model: changes to Trx2 in the auditory cortex - Sun, Hai‐Ying; Hu, Yu‐Juan; Zhao, Xue‐Yan; Zhong, Yi; Zeng, Ling‐Ling; Chen, Xu‐Bo; Yuan, Jie; Wu, Jing; Sun, Yu; Kong, Wen; Kong, Wei‐Jia (The FEBS journal, 2015)
Keywords: age‐related hearing loss; Aging; animal models; Animals; Antioxidants; Antioxidants - metabolism; apoptosis; Apoptosis - genetics; auditory cortex; Auditory Cortex - cytology; Auditory Cortex - metabolism; Auditory Cortex - physiology; Auditory Cortex - ultrastructure; Carrier Proteins - genetics; Carrier Proteins - metabolism; chronic exposure; cortex; Enzymes; galactose; Gene Expression Regulation; Hearing loss; homeostasis; Malondialdehyde - metabolism; MAP Kinase Kinase Kinase 5 - genetics; MAP Kinase Kinase Kinase 5 - metabolism; Mitochondria; Mitochondria - metabolism; oxidant stress; Oxidative Stress; pathogenesis; phenotype; rats; Rats, Sprague-Dawley; reactive oxygen species; signal transduction; speech; Superoxide Dismutase - metabolism; Thioredoxins - genetics; Thioredoxins - metabolism; thioredoxin 2; apoptosis; oxidant stress; thioredoxin 2; auditory cortex; age-related hearing loss