A new epidioxy sterol as an antifouling substance from a Palauan marine sponge, Lendenfeldia chondrodes

• Published in: Journal of natural products (Washington, D.C.) Vol. 62; no. 1; pp. 152 - 154
• Main Authors: Sera, Y. (Marine Biotechnology Institute, Shizuoka, Japan.), Adachi, K, Shizuri, Y
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.01.1999; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Analytical, structural and metabolic biochemistry; ANTIFOULING AGENTS; BELAU; Biological and medical sciences; CHEMICAL COMPOSITION; CHEMICAL STRUCTURE; Chemistry, Medicinal; COMPOSICION QUIMICA; COMPOSITION CHIMIQUE; ESPECTROMETRIA; ESTEROLES; ESTRUCTURA QUIMICA; Fundamental and applied biological sciences. Psychology; Lendenfeldia chondrodes; Life Sciences & Biomedicine; Marine; MYTILUS EDULIS; Mytilus edulis galloprovincialis; MYTILUS GALLOPROVINCIALIS; OCEANIA; OCEANIE; Other biological molecules; PARAZOA; Pharmacology & Pharmacy; Plant Sciences; Science & Technology; SESTERTERPENES; SPECTRAL ANALYSIS; SPECTROMETRIE; SPECTROMETRY; STEROL; STEROLS; STRUCTURE CHIMIQUE; Terpenes, steroids. Hormones; TERPENOIDE; TERPENOIDOS; TERPENOIDS; Micronesia; Oceania; ISEW, Caroline Is., Palau I; Endoperoxide; Steroid; Organic hydroperoxide; Mytilus edulis; Animal origin; Biological activity; Marine environment; Bivalvia; Porifera; Antifouling protection; Isolation; Repellent; Invertebrata; Mollusca; Secondary alcohol; Structural analysis; Sterol
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np980263v

Bioassay-guided fractionation of an extract of a marine sponge, Lendenfeldia chondrodes, has led to the isolation and identification of new epidioxy sterols la and Ib as an inseparable mixture. Two known epidioxy sterols 2 and 3 and three known sesterterpenes 4-6 were also isolated from the same extract. These compounds showed repellent activity against the blue mussel Mytillus edulis galloprovincialis.